PolyMatrix®

Skin inflammation and PolyMatrix®

Once the chronic inflammation starts, it just a matter of time to see what will happen. For sure the cells will start to age faster due to all free radical damage. The next step is like a search for the weakest link. If the skin is not in a good condition the inflammation may show a dramatic impact on the skin. Fine veins in the face might get inflammed due to sunlight or environmental stress. This may lead to rosacea; dark red butterfly shaped skin with pustula's in the damaged skin.

It may also lead to an uncontrolled cell division. The epidermal cells may devide 1,000 times faster than normal, showing flaky skin at all possible spots on the body. The very strong formulation of PolyMatrix® will control all possible ways which may lead to these conditions. It is best to use PolyMatrix® together with OmegaMatrix® until the hypersensitivity has disappeared. Switch subsequently to the cheaper FlexMatrix®. Consult your physician or our website for dietary advice that is beneficial to the prevention of further inflammation.

Take 4 capsules daily, split in two portions taken right before the meal. For best effect, combine with OmegaMatrix (4 grams daily) and reduce intake of red meats and seed oils, containing omega 6. In case of severe inflammation, PolyMatrix® can be taken at a higher doses, like 6 tablets per day, during a short time like one week. This is also the ideal doses for cancer patients to make any treatment more effective. Fot the last category use for one month before reducing back to 4 caps a day and always combine with OmegaMatrix® and Varimune® 100.

Any type of inflammatory (skin) disorder, like Psoriasis, Rosacea, Eczema, Atheroscleroses, Crohn, MS, Lupus, …

The product contains ingredients plant extracts only.

These phytonutrients are very strong COX2 inhibitors and LOX inhibitors, reducing expression of these. They also strongly reduce free radical damage of the entire body. Reducing COX2 and LOX means less pro-inflammatory eicosanoids. It also strongly affects NFKB and TNF-alpha. Added vitamin D3 will downregulate unlimited cell proliferation. Ceramides will strongly improve the skin barrier function to support the protection against environmental negative impact on the skin.

Instead of just addressing one of the problems which leads to inflammation, PolyMatrix addresses all know possible causes leading to these skin disorders and other inflammatory diseases. It takes about 2 months to really benefit from the therapy. In those months it is highly suggested to change nutritional composition to less inflammatory foods. the combined supplements will help the patient to overcome the first few, most difficult months to get the desired results.

Between 4 and 6 tabs daily, depending on level of inflammation and pain.

Orders can be made at the following website: rejuvenal shop.

Here is a list of some studies to show the influence on skin disorders such as psoriasis and rosacea. More studies can be found by following the links from the ingredients.

Role of curcumin in health and disease.

Arch Physiol Biochem. 2008 Apr;114(2):127-49. Pari L, Tewas D, Eckel J. Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India.

Curcumin (diferuloylmethane) is an orange-yellow component of turmeric (Curcuma longa), a spice often found in curry powder. In recent years, considerable interest has been focused on curcumin due to its use to treat a wide variety of disorders without any side effects. It is one of the major curcuminoids of turmeric, which impart its characteristic yellow colour. It was used in ancient times on the Indian subcontinent to treat various illnesses such as rheumatism, body ache, skin diseases, intestinal worms, diarrhoea, intermittent fevers, hepatic disorders, biliousness, urinary discharges, dyspepsia, inflammations, constipation, leukoderma, amenorrhea, and colic. Curcumin has the potential to treat a wide variety of inflammatory diseases including cancer, diabetes, cardiovascular diseases, arthritis, Alzheimer's disease, psoriasis, etc, through modulation of numerous molecular targets. This article reviews the use of curcumin for the chemoprevention and treatment of various diseases.

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Cathelicidins and vitamin D3: multifunctional defense molecules of the skin.

Dtsch Med Wochenschr. 2009 Jan;134(1-2):35-8. Epub 2008 Dec 17.C Peric M, Koglin S, Ruzicka T, Schauber J. Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität München, München, Germany.

The human skin is constantly exposed to microbial pathogens but infections only rarely occur. Innate cutaneous immunity is a primary system for protection against infection, and antimicrobial peptides (AMPs) expressed in skin are essential defence molecules. The AMPs include molecules such as the defensins that were first characterized for their antimicrobial properties as well as other peptides and proteins first known for their activity as chemokines, enzymes, enzyme inhibitors and neuropeptides. Cathelicidins are unique AMPs that act as defensive and signalling molecules. Two different pathways are involved in this function: cathelicidins have direct antimicrobial activity and they also initiate a host of cellular responses in cytokine release, inflammation and angiogenesis. Several skin diseases are associated with cathelicidin dysfunction. In atopic eczema, for example, cathelicidin expression is suppressed, whereas in rosacea cathelicidin peptides are abnormally processed to forms that induce cutaneous inflammation and a vascular response. In psoriasis cathelicidin peptide converts self-DNA to a potent stimulus in an autoinflammatory cascade. Current studies have unexpectedly identified vitamin D3 as a major factor for the regulation of cathelicidin expression. This finding may provide new strategies in the management of infectious and inflammatory diseases of the skin by targeting control of the expression and function of cathelicidin and other AMPs.

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Berry anthocyanins as novel antioxidants in human health and disease prevention.

Mol Nutr Food Res. 2007 Jun;51(6):675-83.
Zafra-Stone S, Yasmin T, Bagchi M, Chatterjee A, Vinson JA, Bagchi D. Research and Development Department, InterHealth Research Center, Benicia, CA, USA.

Edible berries, a potential source of natural anthocyanin antioxidants, have demonstrated a broad spectrum of biomedical functions. These include cardiovascular disorders, advancing age-induced oxidative stress, inflammatory responses, and diverse degenerative diseases. Berry anthocyanins also improve neuronal and cognitive brain functions, ocular health as well as protect genomic DNA integrity. This chapter demonstrates the beneficial effects of wild blueberry, bilberry, cranberry, elderberry, raspberry seeds, and strawberry in human health and disease prevention. Furthermore, this chapter will discuss the pharmacological benefits of a novel combination of selected berry extracts known as OptiBerry, a combination of wild blueberry, wild bilberry, cranberry, elderberry, raspberry seeds, and strawberry, and its potential benefit over individual berries. Recent studies in our laboratories have demonstrated that OptiBerry exhibits high antioxidant efficacy as shown by its high oxygen radical absorbance capacity (ORAC) values, novel antiangiogenic and antiatherosclerotic activities, and potential cytotoxicity towards Helicobacter pylori, a noxious pathogen responsible for various gastrointestinal disorders including duodenal ulcer and gastric cancer, as compared to individual berry extracts. OptiBerry also significantly inhibited basal MCP-1 and inducible NF-kappabeta transcriptions as well as the inflammatory biomarker IL-8, and significantly reduced the ability to form hemangioma and markedly decreased EOMA cell-induced tumor growth in an in vivo model. Overall, berry anthocyanins trigger genetic signaling in promoting human health and disease prevention.

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Green tea: nature's defense against malignancies.

Butt MS, Sultan MT. Crit Rev Food Sci Nutr. 2009 May;49(5):463-73.

National Institute of Food Science and Technology, University of Agriculture, Faisalabad. drmsbutt@yahoo.com

The current practice of introducing phytochemicals to support the immune system or fight against diseases is based on centuries old traditions. Nutritional support is a recent advancement in the domain of diet-based therapies; green tea and its constituents are one of the important components of these strategies to prevent and cure various malignancies. The anti-carcinogenic and anti-mutagenic activities of green tea were highlighted some years ago suggesting that it could reduce the prevalence of cancer and even provide protection. The pharmacological actions of green tea are mainly attributed to polyphenols that includes epigallocatechin-3-gallate (EGCG), epicatechin, epicatechin-3-gallate, epigallocatechin. Green tea and its components effectively mitigate cellular damage arising due to oxidative stress. Green tea is supposed to enhance humoral and cell-mediated immunity, decreasing the risk of certain cancers, and may have certain advantage in treating inflammatory disorders. Much of the cancer chemopreventive properties of green tea are mediated by EGCG that induces apoptosis and promotes cell growth arrest, by altering the expression of cell cycle regulatory proteins, activating killer caspases, and suppressing nuclear factor kappa-B activation. Besides, it regulates and promotes IL-23 dependent DNA repair and stimulates cytotoxic T cells activities in a tumor microenvironment. It also blocks carcinogenesis by modulating the signal transduction pathways involved in cell proliferation, transformation, inflammation and metastasis. The review is intended to highlight the chemistry of green tea, its antioxidant potential, its immunopotentiating properties and mode of action against various cancer cell lines that showed its potential as a chemopreventive agent against colon, skin, lung, prostate, and breast cancer.

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Green tea polyphenol induces caspase 14 in epidermal keratinocytes via MAPK pathways and reduces psoriasiform lesions in the flaky skin mouse model.

Hsu S, Dickinson D, Borke J, Walsh DS, Wood J, Qin H, Winger J, Pearl H, Schuster G, Bollag WB. Exp Dermatol. 2007 Aug;16(8):678-84.

Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, Medical College of Georgia, Augusta, GA 30912, USA. shsu@mail.mcg.edu

Psoriasiform lesions are characterized by hyperproliferation and aberrant differentiation of epidermal keratinocytes, accompanied by inflammation, leading to a disrupted skin barrier with an abnormal stratum corneum. The expression and proteolytic processing of caspase 14, a member of the caspase family which is associated with epithelial cell differentiation, planned cell death, and barrier formation, is altered in psoriatic epidermis. We recently reported that human psoriatic tissues lack normal expression of caspase 14 [J Dermatol Sci37 (2005) 61], and caspase 14 is induced by EGCG, a green tea polyphenol (GTP), in exponentially growing normal human epidermal keratinocytes (NHEK) [J Pharmacol Exp Ther315 (2005) 805]. This suggests that GTPs may have beneficial effects on psoriasiform lesions. The current study aimed to determine whether MAPK pathways are required for GTP-induced caspase 14 expression in NHEK and if GTPs can modulate the expression of pathological markers in the psoriasiform lesions that develop in the flaky skin mouse. The results indicate that the p38 and JNK MAPK pathways are required for EGCG-induced expression of caspase 14 in NHEK. Importantly, topical application of 0.5% GTPs significantly reduced the symptoms of epidermal pathology in the flaky skin mice, associated with efficient caspase 14 processing and reduction in proliferating cell nuclear antigen levels. This suggests that GTP-activated pathways may be potential targets for novel therapeutic approaches to the treatment of some psoriasiform skin disorders.