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Caloric Restriction and Life Span
Eating less, living longer
The effect of caloric restriction on energy metabolism translates into longevity. Caloric restriction decreases energy levels, which leads to the activation of a signalling cascade to enhance longevity. Decreased glucose intake reduces the flow of carbon through the glycolytic pathway and slows down the conversion of ADP to ATP, which eventually alters the NAD+:NADH ratio. SIRT1, which is a NAD+-regulated chromatin deacetylase, prolongs lifespan in response to caloric restriction in lower organisms. Also, signalling by insulin/insulin-like growth factor 1 (IGF-1) is attenuated under these conditions, which allows the FOXO forkhead transcription factors to increase stress resistance (pro-ageing). As extremes in fat mass are inversely related to lifespan, this indicates that PPAR could also affect longevity, although the mechanisms are not yet established.
STUDY SHOWS CHROMEMATE® INCREASES LIFESPAN - Average Lifespan of Test Animals Increased by More than 20 Percent
BENICIA, Calif., November 30, 2005 – ChromeMate®, Rejuvenal’s patented oxygen-coordinated, niacin-bound chromium ingredient, demonstrated its ability to prolong the life span of test animals by more than 20 percent. The study, conducted by researchers at Georgetown University Medical Center (Washington, DC) and Creighton University Medical Center (Omaha, NE), was presented at the 46th Annual Meeting of the American College of Nutrition, September 22-25, 2005, in Kiawah Island, South Carolina.
In the study, rats prone to many of the manifestations of aging were fed diets containing ChromeMate®, which increased their average life span by 22 percent compared to rats fed the same diet without ChromeMate. Rats fed ChromeMate® also experienced lower systolic blood pressure, lower circulating glucose levels, and a trend toward lower, normalized hemoglobin levels, a long-term indicator of blood sugar status. There were no abnormalities in blood chemistry, kidney or liver function in any group. The first death in the ChromeMate group did not occur until week 59, while the first death in the control (placebo) group occurred at week 47. Thirty three percent of the animals in the ChromeMate group lived at least one month beyond the last animal in the control group.
“We’ve long known that niacin-bound chromium provides significant health benefits relative to metabolic syndrome,” stated lead researcher, Harry G. Preuss, M.D. from Georgetown University Medical Center. “These new results open the possibility that ChromeMate niacin-bound chromium may prolong human life as well.” Generically known as chromium nicotinate or chromium polynicotinate, ChromeMate is a unique oxygen-coordinated niacin-bound chromium complex that plays an important role in proper insulin function, maintenance of healthy blood sugar and normal cholesterol levels, normal energy production, and promotion of healthy body weight. ChromeMate is protected by three U.S. patents, four international patents and other worldwide patents pending, and is the only niacin-bound chromium supplement with proven biological activity. Earlier this year, ChromeMate received GRAS status (Generally Recognized as Safe) for use in functional beverages.
Studies:
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