Growth hormone, hGH

Human Growth Hormone and anti aging

RecoveryMatrix® & VitalityMatrix® were designed from a background of information derived from many medical tests and laboratory experiences in the eighties and nineties. Around that time, growth hormone supplements were used for kids with a growth delay. Injections with real growth hormone hGH (hGH=Human Growth Hormone) were useful but very expensive and risky due to side effects. The search started for alternatives…

Our body produces growth hormone during our entire life. It is well known that our body produces high levels of this hormone up to the age of 20 years. Then, a long decline begins. On average, a healthy person will lose about 14% of his hGH production per decade. When stress occurs, or other negative influences, this decrease may even be more dramatic. Our level of hGH is directly coupled to our body’s maintenance system.

Around 1990, Dr. Daniël Rudman at the University of Wisconsin ran a test with a group of elderly persons by injecting them with real hGH. The results were amazing and were published in the New England Journal of Medicine on July 5, 1990. They wrote: “the effects of six months of hGH on lean body mass and adipose tissue mass were equivalent in magnitude to the changes incurred during 10 to 20 years of aging.” Unfortunately, in addition to the extremely high cost of the hGH, there were many side effects that were problematic, mainly due to the large dosages of hGH given to the patients. In the meanwhile many other options had been tested but none of them had any results like these in double blind, placebo control trials. hGH has been tested yet, uncountable times, with the same results, over and over again. Following up on his own work, Rudman found that hGH given to elderly men and women regrew their livers, spleens and muscles that had shrunken with age, back to their youthful sizes. Improved muscle strength could make the difference between someone’s being on his feet or being confined to a wheelchair, between being spoon-fed and cooking a meal, between living independently and living in a nursing home.

It was only in 1996 that the FDA approved the use of hGH for long-term replacement therapy in adults with hGH deficiency. For two decades, hGH has been made in laboratories by manipulation of the E-coli bacterium. Two large companies spend lots of money on research to reproduce this very complex protein of the human body. Today, hGH-injections are available in some countries, for those who need it, and want to spend around some hundreds of Euro’s per month. However, using hGH reduces our own hGH-release even further…

If there is still hGH production available at the pituitary, Recovery- and VitalityMatrix can stimulate this complex system to release more of our own hGH. Testing of these products started more than two decades ago, and are very refined since then. The good news: since it is our body’s own hGH, side effects are unknown, it ALWAYS works, it cannot be overdosed, it is very cost effective and similar results can be produced in very short time. A randomized, double blind and placebo controlled test, done by the University of Amsterdam in 2003, showed an increase of hGH release by 70% after using RecoveryMatrix® for only 3 weeks. No side effects where noted and costs were very low, approximately 2 Euro’s per day. Probably the most important aspect of using Rejuvenal hGH stimulating products is that it is 100% natural. Instead of replacing our own hormones we make our body release more of our own. Because of the naturally occurring protective feedback loop, overdosing is impossible.

Concise Explanation of the hGH-system.
The pituitary has a natural tendency to release hGH, especially when hungry and at low blood sugar levels. Teenagers release hGH in pulses, day and night, while adults only release hGH during their nightly deep sleep phase. (See page 6.) It is commonly accepted that our hGH levels decrease by 14% per decade after age 20. Around our forties it seems to get an extra “dip”. This hGH is of major importance to keep the maintenance system working properly. Less hGH means less maintenance resulting in progressive aging. Factors with an accelerated effect on decreasing hGH-levels are stress, lack of sleep, late sleeping or night duties, over eating or eating late at night. hGH is optimally delivered at a low blood sugar level and during the deep sleep phase. The hypothalamus releases GHRH (Growth Hormone Releasing Hormone). In response on the GHRH the pituitary will release hGH.


hGH is an anabolic hormone so it will stimulate muscle growth in a natural way. It also has insulin like effects. It will lower blood sugar level and save left over glucose for the brain function. The rest of the body then will burn fat only. However, it is important to only use the product on an already existing low blood sugar level, like when feeling hungry or right after arising. The growth hormones enter the bloodstream and reach the liver. They stimulate the liver to release growth factors. There are several different growth factors each of which has a function in the maintenance system of our body. The liver releases most of them, but some growth factors are released from different body parts. The easiest one to measure is the so-called IGF-1 (Insulin like Growth Factor-1). This IGF-1 is responsible for the quality of bone mass, muscles, skin, organs, hair, nails, digestive system, …

If, for some reason, IGF-1 level should raise too high, then the hypothalamus will release somatostatin or GHiH (Growth Hormone inhibiting Hormone). Somatostatin was first discovered in hypothalamic extracts and identified as a hormone that inhibited secretion of growth hormone. Subsequently, somatostatin was found to be secreted by a broad range of tissues, including pancreas, intestinal tract and regions of the central nervous system outside the hypothalamus. The pituitary will stop releasing hGH, therefore the liver will stop producing IGF-1. In that way the feedback loop protects our body against possible overdosing with Rejuvenal hGH stimulators. Since seniors over 60 tend to overproduce somatostatin, the VitalityMatrix® has a special composition to mediate this overproduction. There for it is recommended to advise people past 60 the VitalityMatrix® for better and more consistent results. Although the effects of RecoveryMatrix® are more powerful, the Senior will do the same; it just needs a bit more time. The Rejuvenal products contain several amino acids, which are known to stimulate the hypothalamus to release GHRH. These specific amino acids, in the right mixture and in the right amounts, work very effectively. Overdosing does not offer any better effects. You may start with a lower dose for a short time but build up to the right dose. There needs to be a minimum concentration of these amino acids in the bloodstream to be effective in triggering hypothalamus activity.

HGH-stimulation

The release of growth hormone can be triggered by the intake of supplements, specially designed for this purpose. Two of them are RecoveryMatrix and VitalityMatrix. These products are mainly based on amino acids.

See Wikipedia: http://en.wikipedia.org/wiki/Growth_hormone

 

A study of growth hormone release in man after oral administration of amino acids.

Isidori A, Lo Monaco A, Cappa M.
A study was carried out in 15 male volunteers to evaluate qualitatively the secretion of growth factors following stimulation by oral amino acids. The results showed that oral administration of a combination of two amino acids (1200 mg 1-lysine plus 1200 mg 1-arginine) provoked a release of pituitary somatotropin and insulin. This phenomenon was reproducible and the growth hormone secreted in response to this stimulation had biological activity (as demonstrated by a radioreceptor assay and somatomedin induction). The effect appeared to be specific to the combination of the two amino acids; neither of the amino acids demonstrated appreciable stimulating activity when administered alone, even at the same doses.
PMID: 6790230 [PubMed - indexed for MEDLINE]

Stimulatory effect of glycine on human growth hormone secretion.
Kasai K, Kobayashi M, Shimoda SI.
Glycine (250 ml 0.3 M glycine) was administered orally to 19 nonobese normal subjects and 12 subjects with partial gastrectomy. In the normal subjects, a clear and significant increase of serum human growth hormone (hGH) level was observed (p less than 0.001), whereas serum immunoreactive insulin (IRI), prolactin (PRL) and blood sugar (BS) levels were not affected after the drug administration. A more pronounced and significant increase of hGH value in serum was found in the subjects with gastrectomy than in the normal controls (p less than 0.001). Thus we administered the drug intraduodenally in normal subjects. The similar rise of hGH to that of the gastrectomied group was obtained in normals by this administration. The facts demonstrated that glycine is one of the stimulatory agents inducing the pituitary gland to secrete hGH. In addition, in nonobese diabetics, no significant increase of serum hGH level, even after the intraduodenal administration of glycine, was observed in the present study.
PMID: 622050 [PubMed - indexed for MEDLINE]

Acta Endocrinol (Copenh). 1989 Jun;120(6):767-72.

Growth hormone influences collagen deposition and mechanical strength of intact rat skin. A dose-response study.
Jorgensen PH, Andreassen TT, Jorgensen KD.
Department of Connective Tissue Biology, University of Aarhus, Denmark.
The influence of biosynthetic human growth hormone on biomechanical properties (strain at maximum load, maximum load, relative failure energy, maximum stiffness) and collagen content of intact rat skin was measured after injection of biosynthetic human growth hormone for 90 days at doses of 0.16, 1.10 and 8.33 mg.kg-1.day-1. The mechanical test showed that strain at maximum load, maximum load and relative failure energy increased with increasing doses of biosynthetic hGH. In the group receiving 8.33 mg.kg-1.day-1, skin collagen content per surface area and skin collagen concentration in per cent of dry weight were increased, whereas the fat concentration in per cent of dry weight was decreased. Also when correcting the mechanical data for cross-sectional area, a positive correlation between dose and relative failure energy was found. When dividing the mechanical data by collagen content per surface area of the skin, the maximum stress and relative failure energy reached the highest value at a dose of 1.10 mg.kg-1.day-1. The study shows that biosynthetic hGH can induce an increase in collagen content and mechanical strength of intact rat skin which is dependent on the dose of biosynthetic hGH, and that the increase in mechanical strength cannot be explained only by an increased collagen content. PMID: 2728814 [PubMed - indexed for MEDLINE]