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Inflammation, Eicosanoids, COX 1 & COX 2
Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning.
Aggarwal BB, Shishodia S. Ann N Y Acad Sci. 2004 Dec;1030:434-41.
Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Box 143, 1515 Holcombe Boulevard, Houston, TX 77030, USA. aggarwal@mdanderson.org
The activation of nuclear transcription factor kappaB has now been linked with a variety of inflammatory diseases, including cancer, atherosclerosis, myocardial infarction, diabetes, allergy, asthma, arthritis, Crohn's disease, multiple sclerosis, Alzheimer's disease, osteoporosis, psoriasis, septic shock, and AIDS. Extensive research in the last few years has shown that the pathway that activates this transcription factor can be interrupted by phytochemicals derived from spices such as turmeric (curcumin), red pepper (capsaicin), cloves (eugenol), ginger (gingerol), cumin, anise, and fennel (anethol), basil and rosemary (ursolic acid), garlic (diallyl sulfide, S-allylmercaptocysteine, ajoene), and pomegranate (ellagic acid). For the first time, therefore, research provides "reasoning for seasoning."
Inflammation and mediators
Altern Ther Health Med. 2005 Nov-Dec;11(6):20-7; quiz 28, 75.
Inflammation, pain, and chronic disease: an integrative approach to treatment and prevention.
Edwards T.
Center for Integrative Medicine, USA.
Inflammation is now recognized as an overwhelming burden to the healthcare status of our population and the underlying basis of a significant number of diseases. The elderly generally bear the burden of morbidity and mortality, which may be reflective of elevated markers of inflammation resulting from decades of lifestyle choices. Lower cancer rates are associated with diets high in fiber, fruits, vegetables, and tea. AD and PD may be prevented or treated with aggressive vitamin E, curcumin, acetylcarnitine, and catechin supplementation. Cardiovascular disease, metabolic syndrome, hypertension, diabetes, and hyperlipidemia may be ameliorated by treating the underlying cause: inflammation caused by visceral adipose tissue. It is no longer appropriate to allow our dietary habits to contribute to the morbidity and mortality of the majority of humans. Although there is much more to understand, we have enough information presently to make the necessary changes in our lifestyles to significantly affect the inflammatory process and potentially live longer, healthier lives, with fewer burdens to an overburdened and failing medical system.
Studies:
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