Logo - Rejuvenal
Alkylglycerols
May contribute to healthy influence on cell growth regulation. Alkylglycerols may contribute to health maintenance of cells under extreme stress like cancer or other serious immune problems. Alkylglycerols are found in mothers’ milk (10 times more than in cow milk) and are responsible for building up the immune system from the young born child. Shark liver oil is a major source of alkylglycerols.
Cancer and immune stimulation
The Alkylglycerols contained in our OmegaMatrix® are of significant importance. Studies (found at www.pubmed.com) over the past 30 years have shown that alkylglycerols are multifunctional. When cancer occurs, the level of natural alkylglycerols rises within tumor cells, apparently in an effort to control cell growth. Recent studies indicate that the activation of protein Kinase C, an ominous step in cell proliferation that can be inhibited by alkylglycerols. This action suggests a competitive inhibition of 1.2-diacylglycerol by alkylglycerols. Further studies on the immunostimulatory action of alkylglycerols suggest a primary action on the macrophage. Many studies have proven the very powerful anti-angiogenesis effect on tumors. It substantially slows tumor growth. This effect is achieved by out-competing the protein Kinase C that promotes tumor growth, (J Altern Complement Med. 1998 Spring; 4 (1):87-99, Some biological actions of alkylglycerols from shark liver oil, Pugliese PT, Jordan K, Cederberg H, Brohult J.)
Further studies indicate that Alkylglycerols can do what very few chemical compounds can do: pass across the blood-brain barrier. When combined with chemotherapy agents, Alkylglycerols enhance their efficacy in treating brain tumors. In published studies, Alkylglycerols have been shown to:
• promote the production of blood platelets
• boost the immune system
• have an anti-angiogenic effect
• be “biologically active and promoted a more benign or differentiated phenotype in these colon cancer cells, (J Cell Physiol. 1999 Feb;178(2):173-8. Differentiation-promoting effect of 1-O (2 methoxy) hexadecyl glycerol in human colon cancer cells. Wang H, Rajagopal S, Reynolds S, Cederberg H, Chakrabarty S.)
• prevent the loss of white and red blood cells as well as platelets during radiation therapy.
The synergistic combination of functional nutrients, including the Omega-3s with their broad health benefits, makes OmegaMatrix a sensible approach for optimum health maintenance.
Health properties of shark liver oil
Szostak WB, Szostak-Wegierek D.
Zakład Profilaktyki Chorób, Zywieniowozaleznych z Poradnia Chorób Metabolicznych, Instytut Zywności i Zywienia w Warszawie.
Fish oils are the source of nutrients important for health maintenance. The most significant are essential fatty acids (EFA) of n-3 family, alkylglycerols and squalene. N-3 EFA are of great importance in atherosclerosis prevention. Alkylglycerols and squalene are modulators of immunity to infections and cancer. Shark liver oil contains great amounts of alkylglycerols and squalene, and moderate of n-3 EFA. Therefore, it is used as an adjunctive agent in cancer therapy, especially in radiotherapy, and in the treatment of infectious diseases.
Nutr Cancer. 2004;48(1):64-9.
Natural alkylglycerols restrain growth and metastasis of grafted tumors in mice.
>Pedrono F, Martin B, Leduc C, Le Lan J, Saïag B, Legrand P, Moulinoux JP, Legrand AB.
Laboratoire de Pharmacologie Moléculaire, Faculté de Pharmacie, Rennes, France.
Alkylglycerols are natural etherlipids abundant in shark liver oil (SLO) in a diacylated form. SLO is known to have antitumor properties and was recently described as an inhibitor of tumor neovascularization. However, most studies did not discriminate between the respective activities of alkylglycerols and of fatty acids, which both have potent biological properties. In this work, a mouse model was used to investigate the antitumor effects of SLO and of alkylglycerols purified from the same source, both administered orally. We demonstrated that either pure alkylglycerols or SLO reduced the tumor growth in a similar manner, suggesting that alkylglycerols were involved in this effect. In alkylglycerol-treated mice, metastasis dissemination was reduced by 64 +/- 8%, whereas SLO effect was 30 +/- 9% below control. Purified alkylglycerols also decreased significantly plasmalogen content in tumors, whereas SLO had no such effect. Finally, we demonstrated that a 5-day treatment with alkylglycerols curtailed the presence in tumors of von Willebrand factor, a marker of endothelial cells. This result suggested an anti-angiogenic effect of alkylglycerols. In summary, alkylglycerols were shown to decrease the growth, vascularization, and dissemination of Lewis lung carcinoma tumors in mice. These findings suggest that the antitumor activity of SLO is likely mediated by the presence of alkylglycerols.
Studie1