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Skin health, shock absorption and wrincle reduction

Hyaluronic acid (HA), also called hylaruronan, is the core molecule from proteoglycans. It has a very high molecular weight and therefor it is difficult to absorb out of food. Some resources have very low molecular weight HA. Rejuvenal uses different types; low molecular weight of 15.500 Dalton or high, 500 Kdalton. Both are effective. Low type can be absorbed well in the gut, high type stimulates enzymes in the body to increase the production of new HA-chains. Our body has approx. 15 grams of HA, of which 5 grams is turned over every day.

It has many functions. Most well known is the ability to attract water. This helps to hydrate the skin to maintain a young looking face. But it has similar importance in hydrating joints to maintain the shock absorbing ability to avoid osteo arthritis. Less known is the effect to stimulate bone mass, important to avoid osteoporoses. Read the study below…

Effect of hyaluronan on osteogenic differentiation of porcine bone marrow stromal cells in vitro.

J Orthop Res. 2008 May;26(5):713-20. Zou L, Zou X, Chen L, Li H, Mygind T, Kassem M, Bünger C.
Orthopaedic Research Laboratory, Aarhus University Hospital, 8000 Aarhus C, Denmark.
Hyaluronan (HA) plays a predominant role in tissue morphogenesis, cell migration, proliferation, and cell differentiation. The aims of the present study were to investigate whether (i) prolonged presence of high concentration (4.0 mg/mL) 800 KDa HA and (ii) pretreatment with HA can modify osteogenic differentiation of pig bone marrow stromal cells (pBMSC). Cell proliferation and mineralization were measured. Expression of differentiation-related genes was evaluated by means of real-time reverse transcription polymerase chain reaction (RT-PCR).

HA increased cell proliferation on day 7. HA decreased the basal level of bone-related gene expression and increased the basal level of sox9 marginally during 7-day pretreatment with HA. HA increased calcium deposit on day 21. cbfa1, ALP, and type 1 alpha collagen (Col1) expression was increased when pBMSC were cultivated in osteogenic medium, whereas their expression was decreased in the presence of HA on day 7. On day 14, the addition of HA upregulated cbfa1 and ALP expression compared to osteogenic medium group; there was no significant difference in Col1 expression. At day 21, osteocalcin (OC) expression showed 2.5-fold upregulation over osteogenic medium. These results suggest that exogenous HA stimulates endogenous HA, which together may play a synergetic role in osteogenic differentiation under osteoinducing conditions although gene expression was inhibited at the early stage.

2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.