FlexMatrix®

Connective tissue and joint hydratation

FlexMatrix® is designed to repair cartilage, joints and binding tissue. It makes worn out or irritated joints supple again. FlexMatrix® provides the skin with the necessary nutrients, such as organic sulphur (MSM=MethylSulfonylMethane), needed for viable connections. The results are very fast and much more powerful than most products; more so if combined with the OmegaMatrix®. The joints will recover if the appropriate dosage is used. It also enhances the ability to hydrate the cartilage, which improves the shock absorbing capacity of the joint, depending on the level of damage done to the joints surface.

Use tablets always right after meals. If used before meals, the liver will break down the glucosamine as a resource of energy. Taking it after the meal will help to avoid this.

Osteo Arthritis.

This product contains ingredients derived from fish.

Arthritis and Glucosamine

For optimum effect, combine OmegaMatrix® with the FlexAid®. The combination is ideal in lower dosage, (1 tab a day) to prevent damage. Athletes should take up to 3 tabs daily to keep their joints strong and flexible. The composition is excellent to support the strength and quality of the binding tissue. This is because of the high level of MSM. It improves the elasticity of the skin, which has a powerful anti-aging effect. Together with OmegaMatrix® it’s an optimal combination to fight Rheumatoid Arthritis. (It is even a better choise to go for FlexPro®, combined with OmegaMatrix®).

Research studies on Glucosamine and Chondroitin sulfate (especially from Ray cartilage) showed that these two substances are very useful for bone mass and cartilage building. The combined use of these two nutrients keeps muscles supple after intensive sports. Glucosamine improves the lubrication of joints and muscle sheaths. Chondroitin sulfate is a component of the shark cartilage, which is responsible for conservation of the cartilage. The cartilage in the joints act as a spongelike ‘shock absorber’. For this effect it needs substances to attract fluid.

Joint protection with chondroitin sulfate

Chondroitin sulfate attracts this fluid into the cartilage; every mg attracts a 1000-fold amount of fluid! Without this fluid, cartilage would become malnourished, thinner and more fragile. In this way Chondroitin sulfate is essential in protecting cartilage from damage and also stimulates the regeneration of new cartilage, important for healthy joints. Chondroitin sulfate works best when the molecules are small and easily absorbed by the body. Cheaper forms of chondroitin (mostly offal from cattle) are a waste of money as they are passed through the body without benefit. Not to mention the BSE-risk factor. MSM (methyl-sulfonyl-methane) is a natural resource of sulphur with a high biological availability that is taken up very easily by the human body. It protects the body and skin against free radicals. MSM is also available as a concentrated supplement, MSMPro®, combined with extra ingredients to reduce inflammation; check MSMPro® for more information. It promotes healthy skin, hair and nails. It encourages healthy digestive function, reduces inflammation, relaxes muscles, relieves spasms, aches and pains of every variety, from tender joints and tendonitis to headaches and back pain.

The special processing methods result in a unique quality of so-called glucosaminoglycanes. These partly constitute the materials of our constantly rejuvenating joints. In particular, they provide a shock absorbing function. If our food does not contain enough of these substances, our joints will wear out faster. This is especially true of people who are very active: just think about sportsmen and sportswomen, or people who do heavy physical work. People who very often repeat the same action also run a higher risk. Deficiencies will also arise more easily with older people, whose absorption capacity of nutrients has been reduced.
FlexMatrix® contains all the ingredients to guarantee the building up and the maintenance of elastic joints. Deficiencies may be prevented with a low dose. Increase the dosage if a degeneration of your joints’ elasticity is already noticeable or in the event of heavy strain.

Normal dosage is 3 per day, after meals. In case of severe osteo arthritis up to 6 can be taken. For prevention, 1 or 2 might be sufficient.

Orders can be made at the following website: rejuvenal shop.

Osteoarthritis Cartilage. 2006 Mar 30;

Mixtures of glucosamine and chondroitin sulfate reverse fibronectin fragment mediated damage to cartilage more effectively than either agent alone.

> Homandberg GA, Guo D, Ray LM, Ding L.
Department of Biochemistry and Molecular Biology, University of North Dakota School of Medicine and Health Sciences, Box 9037, Grand Forks, ND 58202, USA.

OBJECTIVE: To test the effectiveness of glucosamine (GluNH(2))-HCl, chondroitin sulfate (CS) and mixtures in protecting cartilage exposed to fibronectin fragments (Fn-fs), an exposure known to enhance catabolic cytokines and matrix metalloproteinases (MMPs).

METHODS: Pharmacologic formulations of GluNH(2) (FCHG49((R))) and CS (TRH122((R))) (Nutramax Laboratories, Inc.) were added at 1, 10 or 100mug/ml singly or in mixtures to bovine cartilage cultures in serum or serum-free conditions with or without Fn-f. Proteoglycan (PG) release into media and remaining cartilage PG content were measured by dye binding analysis and effects on PG synthesis by assays of 35-sulfate incorporation. Effects on MMP-3 and -13 expression were measured by Western blotting of conditioned media.

RESULTS: In serum-free conditions, the agents singly or as mixtures did not block Fn-f mediated matrix degradation. In serum, single agents were weakly effective at 100mug/ml, while the mixture of each agent at 0.1mug/ml decreased PG loss by about 50% by day 7 and at 1mug/ml restored nearly 50% of the PG after 7 days in Fn-f pretreated cartilage. However, both agents singly and as mixtures at 0.1-100mug/ml decreased MMP release. In serum, the single agents at 1-10mug/ml weakly reversed Fn-f mediated PG synthesis suppression, while the mixtures were 100% effective at 1mug/ml.

CONCLUSIONS: GluNH(2) and CS act synergistically in reversing damage and promoting repair at concentrations found in plasma after oral ingestion of these agents. Reversal of PG synthesis suppression correlates more with these activities than suppression of MMP-3 or -13 expression.
PMID: 16581272 [PubMed - as supplied by publisher]

 

Clin Drug Investig. 2004;24(6):353-63.

Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis.

Usha PR, Naidu MU.
Department of Clinical Pharmacology and Therapeutics, Nizam's Institute of Medical Sciences, Hyderabad, India.
OBJECTIVE: Glucosamine, classified as a slow-acting drug in osteoarthritis (SADOA), is an efficacious chondroprotective agent. Methylsulfonylmethane (MSM), the isoxidised form of dimethyl-sulfoxide (DSMO), is an effective natural analgesic and anti-inflammatory agent. The aim of this study was to compare the efficacy and safety of oral glucosamine (Glu), methylsulfonylmethane (MSM), their combination and placebo in osteoarthritis of the knee.

PATIENTS AND DESIGN: A total of 118 patients of either sex with mild to moderate osteoarthritis were included in the study and randomised to receive either Glu 500mg, MSM 500mg, Glu and MSM or placebo capsules three times daily for 12 weeks. Patients were evaluated at 0 (before drug administration), 2, 4, 8 and 12 weeks post-treatment for efficacy and safety. The efficacy parameters studied were the pain index, the swelling index, visual analogue scale pain intensity, 15m walking time, the Lequesne index, and consumption of rescue medicine.

RESULTS: Glu, MSM and their combination significantly improved signs and symptoms of osteoarthritis compared with placebo. There was a statistically significant decrease in mean (+/- SD) pain index from 1.74 +/- 0.47 at baseline to 0.65 +/- 0.71 at week 12 with Glu (p < 0.001). MSM significantly decreased the mean pain index from 1.53 +/- 0.51 to 0.74 +/- 0.65, and combination treatment resulted in a more significant decrease in the mean pain index (1.7 +/- 0.47 to 0.36 +/- 0.33; p < 0.001). After 12 weeks, the mean swelling index significantly decreased with Glu and MSM, while the decrease in swelling index with combination therapy was greater (1.43 +/- 0.63 to 0.14 +/- 0.35; p < 0.05) after 12 weeks. The combination produced a statistically significant decrease in the Lequesne index. All treatments were well tolerated.

CONCLUSION: Glu, MSM and their combination produced an analgesic and anti-inflammatory effect in osteoarthritis. Combination therapy showed better efficacy in reducing pain and swelling and in improving the functional ability of joints than the individual agents. All the treatments were well tolerated. The onset of analgesic and anti-inflammatory activity was found to be more rapid with the combination than with Glu. It can be concluded that the combination of MSM with Glu provides better and more rapid improvement in patients with osteoarthritis.